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Genome data unveiling key genes for multicellularity

Discovery of common principle for cancer-suppression and multicellularity

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Graduate School of Science / Faculty of Science
2016/04/26

© 2016 Hisayoshi Nozaki. Photo credit: Hisayoshi Nozaki.A. Multicellarity in the colonial Volvocales. A Chlamydomonas-like unicellular ancestor might have become multicellular about 200 million years ago, giving rise to the complex multicellular organisms with differentiation of cell functions such as Pleodorina and Volvox. Gonium here studied has primitive 8- or 16-cell body without cellular differentiation. B. Eight-celled body of Gonium pectorale, Eight biflagellate cells of the same size are arranged in four rows of two cells each, and swim in an organized fashion. C. Reproduction of G. pectorale. Each cell divides successively to form the next generation organism.

The colonial Volvocales, a model lineage for studies of multicellularity, and the primitive multicellular organism Gonium
A. Multicellarity in the colonial Volvocales. A Chlamydomonas-like unicellular ancestor might have become multicellular about 200 million years ago, giving rise to the complex multicellular organisms with differentiation of cell functions such as Pleodorina and Volvox. Gonium here studied has primitive 8- or 16-cell body without cellular differentiation. B. Eight-celled body of Gonium pectorale, Eight biflagellate cells of the same size are arranged in four rows of two cells each, and swim in an organized fashion. C. Reproduction of G. pectorale. Each cell divides successively to form the next generation organism.
© 2016 Hisayoshi Nozaki. Photo credit: Hisayoshi Nozaki.

Researchers at the University of Tokyo have demonstrated that a group of cancer-suppressing genes are key to the evolutionary step from single cell to multicellular organisms. This was revealed by whole genome sequencing of Gonium (Gonium pectorale), a primitive member of the Volvocales order of multicellular algae.

Even though human beings are complex multicellular organisms composed of billions of individual cells, we must have been born from unicellular ancestors that experienced a multicellular transition more than one billion years ago. Although evolutionary transitions from unicellular to multicellular can be recognized in various eukaryotic lineages, the evolutionarily key genes in the initial stage of multicellularity have remained a mystery.

Associate Professor Hisayoshi Nozaki at the University of Tokyo Graduate School of Science and an international research group have constructed the whole genome sequence of the primitive multicellular organism Gonium pectorale, which they then compared with the genome data from its unicellular relative Chlamydomonas reinhardtii and the multicellular complex volvocalean species Volvox carteri in which the differentiation of cell functions is prominent, and demonstrated that a cell cycle-regulating gene identical to a human cancer-suppressing gene is key to the evolution of multicellularity. The international group also suggested that the evolution of cell-cycle genes might have occurred in the initial stage of multicellularity, preceding the evolution of genes for the differentiation of cellular functions.

“Among the Volvocales, the whole genomes of the ancestral Chlamydomonas and the most evolved member of the group Volvox were compared in 2010,” says Nozaki. He continues, “This time, we aimed to further our knowledge of the evolution of multicellularity by comparing the full genome of Gonium, an organism at an intermediate stage of multicellularity between the unicellular Chlamydomonas and the multicellular Volvox. In the future, we would like to shed further light on the evolution of multicellularity by deciphering the full genome sequence of other members of the order Volvocales.”

This research was carried out in collaboration with the University of Arizona and the University of Kansas.

Paper

Erik R. Hanschen, Tara N. Marriage, Patrick J. Ferris, Takashi Hamaji, Atsushi Toyoda, Asao Fujiyama, Rafik Neme, Hideki Noguchi, Yohei Minakuchi, Masahiro Suzuki, Hiroko Kawai-Toyooka, David R. Smith, Halle Sparks, Jaden Anderson, Robert Bakarić, Victor Luria, Amir Karger, Marc Kirschner, Pierre M. Durand, Richard E. Michod, Hisayoshi Nozaki & Bradley J. S. C. Olson, "The Gonium pectorale genome demonstrates cooption of cell cycle regulation during the evolution of multicellularity", Nature Communications 7, Article number: 11370, doi: 10.1038/ncomms11370.
Article link (Publication)

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Graduate School of Science

Department of Biological Sciences, Graduate School of Science

Laboratory of Origin of Eukaryote Biodiversity, Department of Biological Sciences, Graduate School of Science (Japanese)

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