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Next-generation schizophrenia research

Multi-modal and prospective study may reveal pathology and clinical biomarkers

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University Hospital
2013/01/31

Longitudinal multi-modal measurements and clinical assessments may reveal the pathophysiology of the onset of schizophrenia, and explore possible clinical biomarkers for prediction of outcome and understanding patients’ current condition. © Shinsuke Koike

“Integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project” for first-episode patients and ultra-high risk individuals for psychosis. The project aims to reveal the pathophysiology of schizophrenia onset, and explore possible clinical biomarkers to predict their outcomes and understand their present conditions. There are only a small number of research faculties adopting this approach over the world, and few in Japan. This project has already presented the preliminary outcomes of genetic and neuroimaging studies, and more studies can be expected exploring the pathology of schizophrenia and candidate biomarkers for predicting outcome.

This study was released online in Schizophrenia Research on 6 December 2012. This study was supported by grants from the Ministry of Health, Labour, and Welfare (MEXT), and the“Development of biomarker candidates for social behavior” project of the Strategic Research Program for Brain Sciences sponsored by MEXT.

Paper

Shinsuke Koike, Yosuke Takano, Norichika Iwashiro, Yoshihiro Satomura, Motomu Suga, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Yukika Nishimura, Syudo Yamasaki, Ryu Takizawa, Noriaki Yahata, Tsuyoshi Araki, Hidenori Yamasue, Kiyoto Kasai,
“A multimodal approach to investigate biomarkers for psychosis in a clinical setting: The integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project”,
Schizophrenia Research Online Edition: 2012/12/6, doi: 10.1016/j.schres.2012.11.012.
Article link

Links

Graduate School of Medicine

Department of Neuropsychiatry, Graduate School of Medicine

Cognitive Psychobiology Research Group, Department of Neuropsychiatry, Graduate School of Medicine (Japanese)

Outpatient Unit for Youth, University of Tokyo Hospital (Japanese)

Department of Youth Mental Health, Graduate School of Medicine (Japanese)

Strategic Research Program for Brain Sciences, MEXT (Japanese)

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