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Pupillary reflex enhanced by light inside blind spot

Shedding light on adaptive systems responding to illumination

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Graduate School of Humanities and Sociology / Faculty of Letters
2015/06/26

© 2015 Ikuya Murakami.Left: Relationship between the blind spot and the optic disk. Right: summary illustrations of results. In each panel, white and blue lights indicate the light stimuli presented outside and inside the blind spot, respectively.

Pupillary light reflex in response to light stimuli inside and outside the blind spot
Left: Relationship between the blind spot and the optic disk. Right: summary illustrations of results. In each panel, white and blue lights indicate the light stimuli presented outside and inside the blind spot, respectively.
© 2015 Ikuya Murakami.

University of Tokyo researchers have found that the light reflex of the pupil is modulated by light stimulation inside the blind spot in normal human observers, even though that light is not perceived.

The human retina contains some 100 million photoreceptor cells. When these are stimulated with light, they communicate that information to the brain and we perceive light. However, the optic nerve and blood vessels pass through the region of the retina called the optic disk, which contains no photoreceptors. Light falling on this blind spot is therefore never consciously seen. On the other hand, if a donut-shaped ring of light is targeting to the area around the blind spot, we perceive it as if light were present inside the blind spot itself as well.

When light falls on the eyes, pupil constriction, called the pupillary light reflex, reduces the pupil diameter with less than one second latency. It is known that the pupillary light reflex depends on the area of impinging light. However, the relationship between the light area and the pupillary light reflex remained unclear in the case of the blind spot, where the physical and perceived light areas were different from each other.

Japan Society for the Promotion of Science Postdoctoral Fellow (PD) Kentaro Miyamoto at the Graduate School of Medicine, and Associate Professor Ikuya Murakami at the Department of Psychology, Graduate School of Humanities and Sociology, discovered that when light impinges on the photoreceptor-free blind spot alone the pupillary reflex does not occur, but the pupillary reflex is enhanced in response to bright illumination in a normal part of the retina when blue or white light containing shorter wavelengths is simultaneously delivered inside the blind spot.

One possible explanation for these seemingly contradictory results is that the blind spot contains the axons of retinal ganglion cells, especially those that are intrinsically photosensitive. Thus, it is proposed that neural signals originating from light reception at photoreceptors are modulated by light reception in these ganglion cells.

Taking advantage of the unique place occupied by the blind spot will make it possible for researchers to further elucidate the processes underlying adaptive controls in response to light stimulation onto the retina, including pupillary reflex and circadian rhythm. “Future research will be directed at possible influences of blind-spot stimulation on conscious or unconscious visual decision processes, and thereby toward the understanding of multiple information processing tracks in the brain,” says Associate Professor Murakami.

Paper

Kentaro Miyamoto and Ikuya Murakami, "Pupillary light reflex to light inside the natural blind spot", Scientific Reports Online Edition: 2015/06/26 (Japan time), doi: 10.1038/srep11862.
Article link (Publication)

Links

Graduate School of Humanities and Sociology

Department of Psychology, Division of General Culture, Graduate School of Humanities and Sociology

Murakami Laboratory, Department of Psychology, Division of General Culture, Graduate School of Humanities and Sociology

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