Research and Development of Innovative Health Care System for eExtension of Healthy Life Span

Interdisciplinary projects of advanced engineering and clinical medicine are based on the understanding of the interaction between the human body and artificial systems. The research projects aim to develop various cost-effective medical technologies that contribute to extending healthy life span. Social implementation will be swiftly realized through conducting appropriate clinical studies to collect scientific evidence to prove the safety and efficacy of the technologies. Specifically, the following four projects are planned:
- Home medical system in which the measurement of appropriate biomarkers for the prevention, diagnosis, and prognosis of diseases is used to serve as a guide for appropriate medical care
- Develop the next-generation diagnostic and therapeutic systems based on comprehensive information processing of various measurement and precise treatment by biological, physical and chemical operations
- Employ medical devices, biomaterials, and functional molecules that promote healing and regeneration of living systems through appropriate spatial and temporal and spatial control of the differentiation and proliferation of cells in vivo
- Use health navigation systems for evacuating personal health risks and providing appropriate advice by integrating personal medical and health information using computer simulations and artificial intelligence

Through cooperation of the Graduate School of Medicine, the Graduate School of Engineering, and the University Hospital, we conduct cyclic research and development activities from basic to clinical, and vice versa, which lead to University-Industry collaboration.

- YRIKEN
- AIST
- IBIOHN
- NIHS
- Hitachi
- Olympus
- Toshiba Medical Systems
- Fujitsu
- NTT
- TANITA
- CHUGAI PHARMAEUTICALS
- Eizai､Kyowa hakko Kirin
- TOSOH
- Sysmex
- Panasonic

- Yabunaka K, Nakagami G, Komagata K, Sanada H. Ultrasonographic follow-up of functional chronic constipation in adults: A report of two cases. SAGE Open Medical Case Reports. 5: 1-4. 2017.
- Jaebum Cho, Yukari Miyake, Ayae Honda, Keiichiro Kushiro, and Madoka Takai. Analysis of the Changes in Expression Levels of Sialic Acid on Influenza-Virus-Infected Cells Using Lectin-Tagged Polymeric Nanoparticles, Frontiers in Microbiology, 7: 1147,2016.
- T. Asano, N. Kubota, N. Koizumi, K. Itani, T. Mitake, K. Yuhashi, H. Liao, M. Mitsuishi, S. Takeishi, and T. Takahashi, "Novel and simple ultrasonographic methods for estimating the abdominal visceral fat area.", International Journal of Endocrinology､in press.
- A. Ishijima, K. Minamihata, S. Yamaguchi, S. Yamahira, R. Ichikawa, E. Kobayashi, M. Iijima, Y. Shibasaki, T. Azuma, and T. Nagamune, "Selective intracellular vaporisation of antibody-conjugated phase-change nano-droplets in vitro," Scientific reports, vol. 7, p. 44077, 2017.
- H. Liao, M. Noguchi, T. Maruyama, Y. Muragaki, E. Kobayashi, H. Iseki, and I. Sakuma, "An Integrated Diagnosis and Therapeutic System using Intra-operative 5-Aminolevulinic-Acid-Induced Fluorescence Guided Robotic Laser Ablation for Precision Neurosurgery," Medical Image Analysis, vol. 16, pp. 754-766, 2012.
- M. Mitsuishi, A. Morita, N. Sugita, S. Sora, R. Mochizuki, K. Tanimoto, Y. M. Baek, H. Takahashi, and K. Harada, "Master-slave robotic platform and its feasibility study for micro‐neurosurgery," The International Journal of Medical Robotics and Computer Assisted Surgery, 2012.
- Kiyoshi M, Caaveiro JM, Kawai T, Tashiro S, Ide T, Asaoka Y, Hatayama K, Tsumoto K : Structural basis for binding of human IgG1 to its high-affinity human receptor FcγRI. ,Nature Commun. 2015 Apr 30;6:6866.
- Kudo S, Caaveiro JM, Nagatoishi S, Miyafusa T, Matsuura T, Sudou Y, Tsumoto K.: Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin., Sci Rep. 2017 Jan 3;7:39518.
- Yamaguchi S, Waki K, Tomizawa N, Waki H, Nannya Y, Nangaku M, Kadowaki T, Ohe K. “Previous dropout from diabetic care as a predictor of patients' willingness to use mobile applications for self-management: A cross-sectional study.”, J Diabetes Investig. 2017 Jul;8(4):542-549.
- Waki K, Fujiu K, Hayashi A, Kimura S, Kobayashi H, Nangaku M, Kadowaki T, Ohe K., DialBetics: Smartphone-Based Self-Management for Type 2 Diabetes Patients on Insulin Injections., J Diabetes Sci Technol. 2016 May 3;10(3):804-5.
- Hayashi A, Yamaguchi S, Waki K, Fujiu K, Hanafusa N, Nishi T, Tomita H, Kobayashi H, Fujita H, Kadowaki T, Nangaku M, Ohe K., Testing the Feasibility and Usability of a Novel Smartphone-Based Self-Management Support System for Dialysis Patients: A Pilot Study., JMIR Res Protoc. 2017 Apr 20;6(4):e63.
- Hayashi K, Okamoto F (co-first author), Hoshi S, Katashima T, Zujur D, Li X, Shibayama M, Gilbert EP, Chung U, Ohba S, Oshika T, Sakai T. Fast-forming hydrogel with ultralow polymeric content as an artificial vitreous body. Nat Biomed Eng 1:0044,2017.
- Zujur D, Kanke K, Lichtler AC, Hojo H, Chung U, Ohba S. Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions. Science Advances 3 (5), e1602875,2017.
- Kazuhiko Ohe: Infrastructure for secondary use of healthcare database Toward multipurpose data analyse, Joho Kanri 2016, vol. 59, no. 5, p. 277-283.(in Japanese)

- Patent number 5590493 (2014/8/8)
- Patent number 5368615 (2013/12/18)
- Patent number 6120180 (2017/4/7)
- Unexamined Japanese Patent Publication number 2017-024991 (2017/2/2)
- Unexamined Japanese Patent Publication number 2015-097496 (2015/5/28)