Complex-systems Biology

The Center for Complex-Systems Biology was founded in the Graduate School of Arts and Sciences in 2004, aiming to elucidate the fundamental principle of life phenomenon that cuts through various hierarchies and scales, through close collaboration between theory and experiments. In particular, we have been uncovering basic principles of underlying stability that helps maintains diversity in a biological system, adaptability against various environmental changes, cooperation of cells to achieve stability in a multicellular system, differentiation and morphogenesis through intercellular interaction, direction and constraint in phenotypic evolution, and so forth (as shown in Fig. 1). The topics related to SDGs also include robustness/homeostasis of complex systems and the development of some experimental technologies in single-cell measurement and imaging (as show in Fig. 2), which have potential applications to medicine. Furthermore, principles for maintaining diversity, which we aim to unveil, will provide fresh perspectives to understand the sustainability of ecosystems and human society. Meanwhile, the uncovered principles on phenotypic evolution will also be relevant to understand the plasticity, resilience, and development of human society.

- Satoshi Sawai
- Yuichi Wakamoto
- Shuji Ishihara
- Moritoshi Sato
- Kunihiro Ohta
- Tatsuo Michiue
- Takashi Ikegami
- Koji Hukushima

- K.Kaneko(2006). Life: an introduction to complex systems biology. Springer
- A.Nakajima et al.Nat.Comm(2014)5
- H.Hashimoto et al, PNAS (2016) 113,3251
- K.Kaneko et al. Phys Rev X(2015) 5, 0110145

- Patent number5231684
- Patent application2016-087745, International patent application PCT/JP2017/015594