Next-generation schizophrenia research Multi-modal and prospective study may reveal pathology and clinical biomarkers
“Integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project” for first-episode patients and ultra-high risk individuals for psychosis. The project aims to reveal the pathophysiology of schizophrenia onset, and explore possible clinical biomarkers to predict their outcomes and understand their present conditions. There are only a small number of research faculties adopting this approach over the world, and few in Japan. This project has already presented the preliminary outcomes of genetic and neuroimaging studies, and more studies can be expected exploring the pathology of schizophrenia and candidate biomarkers for predicting outcome.
This study was released online in Schizophrenia Research on 6 December 2012. This study was supported by grants from the Ministry of Health, Labour, and Welfare (MEXT), and the“Development of biomarker candidates for social behavior” project of the Strategic Research Program for Brain Sciences sponsored by MEXT.
Shinsuke Koike, Yosuke Takano, Norichika Iwashiro, Yoshihiro Satomura, Motomu Suga, Tatsuya Nagai, Tatsunobu Natsubori, Mariko Tada, Yukika Nishimura, Syudo Yamasaki, Ryu Takizawa, Noriaki Yahata, Tsuyoshi Araki, Hidenori Yamasue, Kiyoto Kasai,
“A multimodal approach to investigate biomarkers for psychosis in a clinical setting: The integrative neuroimaging studies in schizophrenia targeting for early intervention and prevention (IN-STEP) project”,
Schizophrenia Research Online Edition: 2012/12/6, doi: 10.1016/j.schres.2012.11.012.