EVENTS
分子病態医科学部門 セミナー開催のお知らせ
基本情報
| 区分 | 講演会等 |
|---|---|
| 対象者 | 社会人・一般 / 在学生 / 留学生 / 卒業生 |
| 開催日（開催期間） | 2019年8月28日 11時 — 12時 |
| 開催場所 | 本郷地区 |
| 会場 | 臨床研究棟A 9階 914室 |
| 参加費 |
無料
|
| 申込方法 | 事前申込不要 |
| お問い合わせ先 | 東京大学大学院医学系研究科 疾患生命工学センター 分子病態医科学部門 Tel：03-5841-1436 E-mail：miya@m.u-tokyo.ac.jp |
Jean Pieters教授によるセミナーを開催します。
Speaker: Jean Pieters, Ph.D.,
Biozentrum, University of Basel, Switzerland
Title: Immune Cell Activation and the Control of Pathogenic stimuli
Our laboratory is investigating the mechanisms that are involved in immune cell activation upon triggering by diverse stimuli. Among the contributions of the laboratory to a better understanding of immunity are the characterization of the intracellular events leading to antigen presentation, the identification of immune evasion mechanisms employed by the human pathogen Mycobacterium tuberculosis within macrophages and the discovery of a leukocyte specific signaling pathway essential for T cell survival. One long-standing interest has been to decipher the role of the immunoregulatory protein coronin 1 in T cell biology. Our recent work suggests that coronin 1 modulates cAMP-dependent signaling, and that targeting coronin 1 results in allograft-specific tolerance without compromising pathogen-specific immunity and in the absence of immunosuppression-associated comorbidities. In my seminar, I will discuss the background of these findings as well as our recent results and talk about potential implications of this work.
Speaker: Jean Pieters, Ph.D.,
Biozentrum, University of Basel, Switzerland
Title: Immune Cell Activation and the Control of Pathogenic stimuli
Our laboratory is investigating the mechanisms that are involved in immune cell activation upon triggering by diverse stimuli. Among the contributions of the laboratory to a better understanding of immunity are the characterization of the intracellular events leading to antigen presentation, the identification of immune evasion mechanisms employed by the human pathogen Mycobacterium tuberculosis within macrophages and the discovery of a leukocyte specific signaling pathway essential for T cell survival. One long-standing interest has been to decipher the role of the immunoregulatory protein coronin 1 in T cell biology. Our recent work suggests that coronin 1 modulates cAMP-dependent signaling, and that targeting coronin 1 results in allograft-specific tolerance without compromising pathogen-specific immunity and in the absence of immunosuppression-associated comorbidities. In my seminar, I will discuss the background of these findings as well as our recent results and talk about potential implications of this work.
