Understanding human brain through constructing organoid circuit tissues

Our project aims to create brain-like tissue from human induced pluripotent stem (iPS) cells and let them acquire functions. After human iPS cells are cultured as a sphere, brain-like tissues (cerebral organoids) start to develop spontaneously. Our project team has developed a unique method to create neural circuit tissues by connecting organoids through numerous axons extended from neurons in organoids. Interestingly, activity of connected organoids is more intense and complex than previously reported. In this project, we will build an AI system that optimizes external stimuli patterns and efficiently trains the connected organoid tissues. Our ultimate goal is to develop tissues with spontaneous higher-order functions.

SoftBank