Prevention and Treatment of Dementia and Alzheimer’s Disease

  • SDG3 Ensure healthy lives and promote well-being for all at all ages
  • SDG8 Promote sustained, inclusive and sustainable economic growth, full and productive employment and decent work for all
  • SDG9 Build resilient infrastructure, promote inclusive and sustainable industrialization and foster innovation
  • SDG11 Make cities and human settlements inclusive, safe, resilient and sustainable
  • SDG17 Strengthen the means of implementation and revitalize the global partnership for sustainable development
Takeshi Iwatsubo
Graduate School of Medicine
Department of Neuropathology Professor
Now that the total number of individuals with dementia in Japan exceeds five million, research and development of strategies for prevention and therapeutics of Alzheimer’s disease (AD) are urgent issues. Our project aims to promote research on elucidating the mechanisms of disorders leading to dementia and development of therapies at the very early stage of AD, thereby addressing various problems with dementia and establishing a healthy aging society.
In the brains of patients with Alzheimer’s disease, deposition of senile plaques (green arrows) and neurofibrillary tangles (pink arrows) cause neuronal death, thereby leading to the symptoms of dementia.
In Alzheimer’s brains, amyloid β proteins start to get deposited before clinical symptoms become manifested, which can now be visualized by PET imaging in living brains.

Related links

Research collaborators

- University of Southern California
- Harvard University
- National Center for Neurology and Psychiatry
- National Center for Geriatrics and Gerontology
- Tohoku University
- Osaka University

Related publications

- Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T: The role of presenilin cofactors in the γ-secretase complex. Nature 422:438-441, 2003
- Iwatsubo T, Iwata A, Suzuki K, Ihara R, Arai H, Ishii K, Senda M, Ito K, Ikeuchi T, Kuwano R, Matsuda H, Sun CK, Beckett LA, Petersen RC, Weiner MW, Aisen PS, Donohue MC: Japanese and North American Alzheimer’s Disease Neuroimaging Initiative studies: harmonization for international trials. Alzheimers Dementia 14:1077-1087, 2018
- Eguchi T, Kuwahara T, Sakurai M, Komori T, Fujimoto T, Ito G, Yoshimura SI, Harada A, Fukuda M, Koike M, Iwatsubo T: LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis. Proc Natl Acad Sci USA 115:E9115-E9124, 2018


  • Graduate School of Meidcine
  • Tel: +81-3-5841-3541
  • Email: iwatsubo[at]
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