Health and longevity through improvement of gut microbial condition by intestinal IgA

Dysbiosis (an impaired gut microbiota) is associated with a variety of diseases including not only gastrointestinal diseases but also cancer, metabolic diseases, autoimmune diseases and so on, although definition of dysbiosis has not been determined yet. Intestinal IgA is a candidate as gut microbial modulator. This project aims to improve or treat dysbiosis by intestinal IgA leading to health and longevity.

- Okai S, Usui F, Ohta M, Mori H, Kurokawa K, Matsumoto S, Kato T, Miyauchi E, Ohno H, Shinkura R. Intestinal IgA as a modulator of the gut microbiota. Gut Microbes. 2017 Apr 6:1-7.
- Okai S, Usui F, Yokota S, Hori-I Y, Hasegawa M, Nakamura T, Kurosawa M, Okada S, Yamamoto K, Nishiyama E, Mori H, Yamada T, Kurokawa K, Matsumoto S, Nanno M, Naito T, Watanabe Y, Kato T, Miyauchi E, Ohno H, Shinkura R. High-affinity monoclonal IgA regulates gut microbiota and prevents colitis in mice. Nat Microbiol. 2016 Jul 4;1(9):16103.